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Preoperative Serum FGF19 in the Prognosis of Biliary Atresia

Preoperative Serum FGF19 in the Prognosis of Biliary Atresia

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Overview

To investigate the role of preoperative serum FGF19 level in the prognosis of biliary atresia.

Description

Kasai portoenterostomy is currently one of the main treatment methods for biliary atresia, but about 30% of children still require liver transplantation even after receiving the surgery. Accurate prognosis will help select the most suitable treatment method for children, but there is currently a lack of effective preoperative predictive indicators. Serum FGF19 has recently been considered a possible preoperative predictive indicator for biliary atresia, but its predictive value has not been confirmed in a large sample and in Asian population, thus the investigators try to further explore the prognostic value of serum FGF19 in children with biliary atresia based on a large sample.

Eligibility

Inclusion Criteria:

  • Samples diagnosed as biliary atresia in Children's Hospital of Fudan University
  • Samples with one-year follow-up records after surgery
  • Samples with a record of serum total bilirubin levels three months after surgery
  • Samples with preoperative serum left（volume > 500ul)

Exclusion Criteria:

  • None

Study details
    Biliary Atresia
    Prognosis

NCT05848310

Children's Hospital of Fudan University

15 October 2025

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