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Local Anesthesia for Facial Fractures

Local Anesthesia for Facial Fractures

Recruiting
18 years and older
All
Phase 2

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Overview

The study is a double-blind randomized, placebo controlled trial examining the impact of perioperative bupivacaine nerve block on PACU recovery metrics. Patients with operative facial fractures are randomized to receive either bupivacaine or saline injections prior to the anesthesia emergence.

Description

Effective pain management is critical to successful postoperative care and is known to decrease patient morbidity, incurred patient and hospital costs, and length of hospital stay. Pain and nausea after surgery for traumatic facial fractures can limit patients' early morbidity, oral intake, and ability to communicate.

The study is a double-blind randomized, placebo controlled trial examining the impact of perioperative bupivacaine nerve block on PACU recovery metrics. Patients with operative mandibular or midface fractures are randomized to receive either bupivacaine or saline injections prior to the anesthesia emergence. The primary outcome measure is the amount of opioid that patients receive in PACU in morphine milligram equivalent (MMEs).

The purpose of the study is to define whether a perioperative bupivacaine nerve block results in a decrease in the amounts of opioids and antiemetics that patients receive in PACU after CMF trauma surgery.

Eligibility

Inclusion Criteria:

  1. Adults age 18 and over
  2. Isolated facial fracture to the mandible and/or midface undergoing surgical repair
  3. No allergy to local anesthetic
  4. Ability to read, write, and understand English

Exclusion Criteria:

  1. Patients under the age of 18
  2. Isolated nasal bone fracture
  3. Polytrauma (I.e. injury pattern resulting in hospital admission for multiple bony fractures outside of the face)
  4. Allergy to local anesthetic

Study details
    Pain Management

NCT06429501

Washington University School of Medicine

21 October 2025

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