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Novel Augmentation of DAOIB and Antioxidant for Early Dementia

Novel Augmentation of DAOIB and Antioxidant for Early Dementia

Recruiting
50-90 years
All
Phase 2
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Overview

Previous studies found that some NMDA-enhancing agents were able to improve cognitive function of patients with early-phase dementia. In addition, several drugs with antioxidant properties have been tested in clinical trials for the treatment of dementia too. Whether combined treatment of an NMDA-enhancing agent and a drug with antioxidant property can be better than an NMDA-enhancing agent alone deserves study.

Eligibility

Inclusion Criteria:

  • Clinical diagnosis of Alzheimer's disease or mild cognitive impairment
  • MMSE between 10-26
  • CDR 1 or 0.5

Exclusion Criteria:

  • Hachinski Ischemic Score > 4
  • Substance abuse/dependence
  • Parkinson disease, epilepsy, dementia with psychotic features
  • Major depressive disorder
  • Major physical illnesses
  • Severe visual or hearing impairment

Study details
    Alzheimer Disease
    Mild Cognitive Impairment

NCT06467539

Chang Gung Memorial Hospital

15 October 2025

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