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The Predictive Value of Doppler Based Renal Ultrasound and Urinary Oxygen Tension for Prediction of Acute Kidney Injury After Open Heart Surgery

The Predictive Value of Doppler Based Renal Ultrasound and Urinary Oxygen Tension for Prediction of Acute Kidney Injury After Open Heart Surgery

Recruiting
21 years and older
All
Phase N/A

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Overview

This study aims to investigate the predictive value of Doppler-based renal ultrasound and urinary oxygen tension in the development of acute kidney injury after cardiac surgery.

Description

Cardiac surgery-associated acute kidney injury (CSA-AKI) is a complication following cardiac surgery occurring in 15-30% of patients. It is associated with increased morbidity and mortality as well as prolonged hospital stay and higher medical costs.

The renal artery pulsatility index (RAPI), which is determined using Doppler measurements, has been reported to detect patients with a high risk of AKI. Additionally, the renal resistance index (RRI), measured by Doppler ultrasound, can accurately predict the occurrence of AKI.

Urinary oxygen partial pressure in the bladder has been shown to decrease in the setting of sepsis, reduced renal blood flow, and decreased cardiac output.

Eligibility

Inclusion Criteria:

  • Age above 21 years.
  • Both sexes.
  • Undergoing elective on-pump cardiac surgery.

Exclusion Criteria:

  • Patients with chronic kidney disease.
  • Patients with any renal pathology or anatomic kidney abnormalities.
  • Patients on renal replacement therapy.

Study details
    Doppler-Based Renal Ultrasound
    Urinary Oxygen Tension
    Acute Kidney Injury
    Open Heart Surgery

NCT07037485

Tanta University

15 October 2025

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