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Efficacy and Safety of Photodynamic Therapy for Cervical and Vaginal Intraepithelial Neoplasia

Efficacy and Safety of Photodynamic Therapy for Cervical and Vaginal Intraepithelial Neoplasia

Recruiting
18-65 years
Female
Phase N/A
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Overview

To investigate the efficacy and safety of photodynamic therapy (20% 5-amino-ketovalerate 630nm red light) in the treatment of cervical and vaginal intraepithelial neoplasia in women in the real world.

Eligibility

Inclusion Criteria:

  • cervical/vaginal high-grade squamous intraepithelial lesions (HSILs) confirmed by colposcopy and pathological biopsy (CIN2 /CIN3 and/or VaIN2/ VaIN3) or persistent CIN1/VaIN1 lasting for more than one year with a strong willingness to treat;
  • colposcopy was adequate, and analysable colposcopy images were retained;
  • endocervical curettage (ECC) did not suggest higher-grade lesions.

Exclusion Criteria:

  • coexistence or suspicion of cancer;
  • porphyria or suspected allergies to red and blue light;
  • severe medical comorbidities；

Study details
    Precancerous Cervical Lesion

NCT06982976

Peking University Third Hospital

15 October 2025

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