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Bracing and Reconstruction of the Anterior Cruciate Ligament for Efficacy Trial

Bracing and Reconstruction of the Anterior Cruciate Ligament for Efficacy Trial

Recruiting
14-39 years
All
Phase N/A

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Overview

Several attempts have been made to reduce these failure rates and improve return to sports rates in high-risk populations, and one of these approaches has been postoperative bracing. A recent survey of the Anterior cruciate ligament (ACL) Study Group has shown that 53% of surgeons prefers functional bracing following ACL reconstruction. Currently, however, there is no clear consensus on whether functional bracing following ACL reconstruction leads to lower failure rates, improved stability or better patient-reported outcomes when compared to ACL reconstruction without bracing.

Description

Given the increased popularity in quadriceps tendon graft, the biomechanical advantages of postoperative functional bracing, and the graft elongation that occurs predominantly with soft tissue grafts, there might be a role for functional bracing following quadriceps ACL reconstruction. Additionally, no studies to date have assessed the role of psychological readiness of return to sport, kinesiophobia and return to sport rates with and without functional bracing following ACL reconstruction (ACLR).

The purpose of this randomized controlled trial is to assess the 2-year outcomes of psychological readiness, patient-reported outcome measures (PROMs), clinical stability, return to sport and failure rates following quadriceps autograft ACL reconstruction with and without functional bracing in the postoperative phase in younger athletic patients and military patients with a higher risk of failure or not returning to sports or duty, respectively, in a randomized study: the Bracing and Reconstruction of the Anterior Cruciate Ligament for Efficacy trial (BRACE-trial).

Eligibility

Inclusion Criteria:

  • patients with unilateral complete ACL injury
  • patients involved in sports and the desire to return to sports
  • patients undergoing quadriceps autograft ACL reconstruction
  • must be 14 to 39 years old

Exclusion Criteria:

  • multiligamentous knee injuries defined as two ligaments requiring surgical stabilization
  • concomitant suture tape augmentation, extra-articular tenodesis or anterolateral ligament reconstruction
  • concomitant femoral, tibial, or patellar fracture(s)
  • patients with significant osteoarthritis
  • concomitant ipsilateral knee dislocation or patellar dislocation
  • significant lower leg malalignment requiring correcting osteotomies
  • prior ACL surgery, including contralateral knee
  • pregnancy during injury or surgery
  • unable to provide consent
  • prolonged use of prednisolone or cytostatics
  • comorbidities (e.g., muscular, neurological, vascular) that influence rehabilitation

Study details
    Anterior Cruciate Ligament Injuries

NCT06942754

Wake Forest University Health Sciences

15 October 2025

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