Overview
The goal of this clinical trial is to assess the effectiveness of non-steroidal anti-inflammatory drugs (NSAIDs) for prophylactic pain relief compared to on-demand pain relief during medical abortion for pregnancies between 13 and 22 weeks at Hung Vuong Hospital in Ho Chi Minh City. The main questions it aims to answer are:
- Does prophylactic use of NSAIDs reduce pain compared to on-demand use during medical abortion?
- What are the potential adverse effects of NSAIDs in this context?
Researchers will compare a group receiving prophylactic NSAIDs to a control group receiving on-demand pain relief to determine if the prophylactic approach leads to improved pain management outcomes.
Participants will:
- Be given NSAIDs either as a preventative measure or upon the onset of pain.
- Be monitored for pain levels using validated pain scales, any side effects, and outcomes of the abortion procedure.
Eligibility
Inclusion Criteria:
- Pregnant women aged 18 years or older.
- No mental illness.
- Gestational age between 13 and 22 weeks (based on the last menstrual period with a regular menstrual cycle and accurate recall of the last menstrual period, or based on a first-trimester ultrasound) with an indication of stillbirth, fetal malformation requiring termination, or voluntary abortion with counseling and understanding of the abortion procedure.
- Willing to participate in the study.
- Capable of reading and signing the informed consent form.
- Able to provide personal information independently.
Exclusion Criteria:
- Medical conditions contraindicating medical abortion: bleeding disorders, anticoagulant use, moderate to severe anemia.
- Cardiovascular conditions: heart failure, mitral valve stenosis, embolism, uncontrolled hypertension.
- Other medical conditions: renal failure, adrenal gland disorders, severe asthma, liver and biliary diseases, glaucoma.
- Active pelvic inflammatory disease or acute genital infections.
- Previous uterine surgery.
- Placenta previa or central placenta previa.
- Uterine malformations.
- History of allergy to NSAIDs, Mifepristone, or Misoprostol.
- Unwillingness to participate in the study.