Overview
The aim of this project is to investigate the physiological effects of intake of long-chain fatty acids (LCFA) and medium-chain fatty acids (MCFA) in patients with Medium-Chain Acyl-CoA Dehydrogenase Deficiency (MCADD) and healthy individuals
Description
Male and female MCADD patients and healthy individuals will be included in this study which is a randomized intervention study in a cross over design consisting of two separate test days.
The study involves two test days of four hours each, during which the participants ingests either medium-chain fatty acids (MCFA) or long-chain fatty acids (LCFA) in the form of triacylglycerol oils. The order of fatty acid oils ingested is determined by randomization.
Eligibility
Inclusion Criteria MCADD patients:
- Male or female
- Age between 18-80 years old
- Diagnosed Medium-chain acyl-CoA dehydrogenase deficiency (MCADD
Inclusion Criteria Healthy Participants:
- Male or female
- Age between 18-80 years old
Exclusion Criteria both MCADD patients and healthy participants:
- Diabetes
- Kidney- or liver disease
- Use of beta blockers or diuretics
- Pregnant, lactating or planning to become pregnant within the study period
- Regular intake of substantial amounts of coconut oil, palm kernel oil or any other source abundant in MCFA
- Ongoing cancer treatment
- Metabolic or absorptive disorders, gastric bypass operation, or use of medication affecting metabolism or food absorption
- Inability, physically or mentally, to comply with the procedure required by the study protocol as evaluated by the primary investigator, study manager or clinical responsible