Overview
The goal of this study is to improve the diagnosis of urinary tract infections (UTI) in older people (≥65 years). The main research questions are:
Research questions
- What is the optimal cut-off for each individual biomarker NGAL,IL-6,AZU,TIMP2 and CXCL9 and associated, sensitivity, specificity, negative and positive predictive value.
- sensitivity, specificity, negative and positive predictive value of a urine leukocyte count cut-off of 200 cells/microL (validation)
- What is the optimal combination of biomarkers for UTI diagnosis in older patients
- As a secondary objective this study aims to evaluate the association between the levels of individual biomarker levels and 1) duration of symptoms 2) complications, 3) recurrence of UTI within 2 months, and length of hospital stay. Next to this, the performance of the astrego PA100 will be validated in diagnosing bacteriuria.
Participants will:
- be asked to provide a urine sample once at the beginning of the study
- be asked to answer some questions about their symptoms and overall health at the beginning of the study and after 8 weeks
- have their vital parameters (temperature and blood pressure) measured once at the beginning of the study
Eligibility
Inclusion criteria:
- Age 65 years or older
- Clinically suspected UTI by treating physician
- Sufficient understanding of the Dutch language
Exclusion criteria:
- Inability to obtain urine
- Inability to provide written consent
- The presence of an indwelling catheter