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Pembrolizumab in Combination With Salvage Chemotherapy for First-relapsed or Refractory Classical Hodgkin Lymphoma

Pembrolizumab in Combination With Salvage Chemotherapy for First-relapsed or Refractory Classical Hodgkin Lymphoma

Recruiting
18-65 years
All
Phase 2
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Overview

The aim of this trial is to develop an effective and well-tolerated regimen for treatment of r/r cHL by introducing the anti-PD-1 antibody pembrolizumab and adding it to well-established chemotherapy regimens (ICE, DHAP). Synergistic effects of conventional agents with checkpoint inhibition may facilitate a highly effective therapy with limited toxicity, which might eventually substitute the very toxic high-dose chemotherapy (HDCT).

Eligibility

Inclusion Criteria:

  • Histologically confirmed first relapse of cHL or primary refractory cHL

Exclusion Criteria:

  • Nodular lymphocyte-predominant Hodgkin lymphoma or composite lymphoma

Study details
    Classical Hodgkin Lymphoma

NCT04838652

University of Cologne

15 October 2025

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