Overview
The efficacy and safety of non-myeloablative and myeloablative preconditioning followed by dual-unit umbilical cord blood transplantation from unrelated donors in adult patients with malignant hematologic diseases eligible for allogeneic hematopoietic stem cell transplantation are evaluated through prospective observation and analysis of actual clinical data collection
Eligibility
Inclusion Criteria:
- (1) Aged 19 and older (2) Patients scheduled for umbilical cord blood
transplantation as a primary allogeneic hematopoietic stem cell transplantation for
the treatment of the following hematologic diseases:
- Acute leukemia (myeloid/lymphoid/mixed lineage) planned for transplantation for
treatment purposes
- Myelodysplastic syndromes planned for transplantation for treatment purposes ③ Chronic leukemia (myeloid/lymphoid/monocytic) and myeloproliferative neoplasms planned for transplantation for treatment purposes ④ Malignant lymphomas, multiple myeloma planned for transplantation for treatment purposes ⑤ Other malignant hematologic malignancies planned for transplantation for treatment purposes ⑥ Planned for transplantation for the treatment of bone marrow failure diseases, including aplastic anemia (3) If all contents of the consent form are understood and consented to in writing.
- Acute leukemia (myeloid/lymphoid/mixed lineage) planned for transplantation for
treatment purposes
Exclusion Criteria:
- (1) Patients with a history of allogeneic hematopoietic stem cell transplantation or
those undergoing transplantation for the treatment of engraftment failure (secondary
allogeneic hematopoietic stem cell transplantation is an exclusion criterion;
however, patients eligible for registration include those undergoing their first
allogeneic stem cell transplantation following an autologous stem cell
transplantation).
(2) Patients with severe, uncontrolled infections or severe cardiopulmonary dysfunction, as judged by the investigator.
(3) Patients with an ECOG Performance Status (PS) greater than 3 or those receiving mechanical ventilation in the intensive care unit.
(4) Patients who do not consent to participate in the study or those deemed unsuitable for sincere participation by the attending physician.