Overview
The purpose of this Study is to assist in implementing a practical, easy-to-adopt lifestyle intervention that optimizes patient outcomes and minimizes pancreatic ductal adenocarcinoma (PDAC) risk.
Eligibility
Inclusion Criteria:
- Age 18 years or older
- Endoscopically, radiologically, or biopsy-proven pancreatic intraductal papillary mucinous neoplasm (IPMN) over 15 mm in size
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- Ability to sign informed consent
- Ability to read and speak English or Spanish
- Body Mass Index (BMI) greater than or equal to 25 kg/m2
- Visceral obesity based on MRI quantification of visceral and subcutaneous fat; ratio of visceral to subcutaneous fat area greater than 0.4 and/or elevated cytokine, incretin or adipokine biomarkers
Exclusion Criteria:
- No diagnosis of an IPMN
- IPMN with high grade dysplasia, cancer or other high-risk features
- Screen failure for exercise safety
- Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease
- Recent fracture or acute musculoskeletal injury
- Numeric pain rating scale of 7 or more out of 10
- Myopathic or rheumatologic disease that impacts physical function