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Evaluation of Efficacy and Safety of VX-993 for Pain Associated With Diabetic Peripheral Neuropathy

Evaluation of Efficacy and Safety of VX-993 for Pain Associated With Diabetic Peripheral Neuropathy

Recruiting
18-80 years
All
Phase 2

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Overview

The purpose of this study is to evaluate the efficacy, safety, and tolerability of VX-993 in participants with pain associated with Diabetic Peripheral Neuropathy (DPN)

Eligibility

Key Inclusion Criteria:

  • Diagnosis of diabetes mellitus type 1 or type 2 with
    • Glycosylated hemoglobin A1c (HbA1c) less than or equal to (≤) 9% and
    • Presence of bilateral pain in lower extremities due to DPN (defined as a symmetric, length-dependent sensory or sensorimotor polyneuropathy) for at least 1 year

Key Exclusion Criteria:

  • Painful neuropathy other than DPN
  • History of cardiac dysrhythmias requiring anti-arrhythmia treatment(s)
  • History of a clinical atherosclerotic event, such as myocardial infarction or stroke, within the past 12 months

Other protocol defined Inclusion/Exclusion criteria may apply.

Study details
    Diabetic Peripheral Neuropathic Pain

NCT06619860

Vertex Pharmaceuticals Incorporated

1 November 2025

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