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Moderate-Intensity Exercise and Pain Sensitization in Breast Cancer Survivors: A Case-Based Study

Moderate-Intensity Exercise and Pain Sensitization in Breast Cancer Survivors: A Case-Based Study

Recruiting
Female
Phase 1/2
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Overview

The aim of this study was to evaluate the feasibility, safety, and acceptability of a supervised, combined moderate-intensity aerobic and resistance training program designed to reduce pain sensitization in BCS with persistent pain. Secondary objectives included assessing changes in pain intensity, somatosensory sensitivity, and temporal summation, while tertiary objectives focused on improvements in quality of life and functional capacity.

Eligibility

Inclusion Criteria:

  • Adult women diagnosed with stage I-III breast cancer
  • Completion of active treatment (surgery, chemotherapy, and/or radiotherapy) at least 6 months prior to enrollment
  • Presence of persistent pain or altered sensation in the upper quadrant of the affected limb related to oncologic treatment

Exclusion Criteria:

  • Bilateral breast cancer
  • Locoregional recurrence
  • Other malignancies
  • Pre-existing pain not related to cancer treatment
  • Neurological or cognitive disorders
  • Non-Spanish speakers
  • Contraindications to moderate-intensity physical activity

Study details
    Exercise Training
    Breast Cancer
    Pain Management

NCT07128030

Universidad Rey Juan Carlos

15 October 2025

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