Overview
The purpose of this study is to evaluate the safety and feasibility of transcutaneous auricular Vagus Nerve Stimulation (taVNS) paired with upper-limb rehabilitation in adults with tetraplegia caused by cervical spinal cord injury.
Eligibility
Inclusion Criteria:
- diagnosis of traumatic incomplete (AIS B-D) cervical spinal cord injury (C8 and above)
- at least 12 months post-traumatic SCI but less than 10 years post-SCI
- demonstrate some residual movement in the upper limb (e.g., able to perform pinch movement with thumb and index finger sufficient to grip small objects such as marble)
Exclusion Criteria:
- non-traumatic SCI
- recent ear trauma and skin lesions at the site of stimulation, such as sunburn, cuts, and open sores,
- facial or ear pain,
- allergic reaction to adhesives and electrodes,
- any current or past history of cardiovascular disorders,
- intracranial metal implants, pacemakers,
- concomitant clinically significant brain injury,
- receiving medication that may significantly interfere with the actions of VNS on neurotransmitter systems at study entry
- If there is a plan for alteration in upper-extremity therapy or medication for muscle tone during the course of the study;
- medical or mental instability;
- pregnancy or plans to become pregnant during the study period