Overview

This study will look at whether motivational sessions (including regular calls with a trained health coach) in combination with time-restricted eating (TRE) is an effective way to achieve weight loss and lower cardiometabolic risk in adult survivors of childhood cancer. The researchers will look at how effective this intervention is compared to the usual approach, which is to review educational materials and measure weight once a month. This study will not provide treatment for any disease or cancer.

Eligibility

Inclusion Criteria:

• Enrolled in the Childhood Cancer Survivor Study (a cohort of 5+ year survivors of childhood cancer diagnosed at age < 21 between 1970-1999 at 31 participating institutions in North America)
• Previously treated with radiation to the chest, abdomen, or total body
• Are ≥18 years old
• Self-reported body mass index ≥ 25 kg/m2
• Are not pregnant or do not intend to become pregnant in the next year
• Stable weight over the past 6 months (+/- 10 pounds)
• If on oral medication for insulin resistance (ie, metformin), elevated blood pressure, or dyslipidemia, medication dose must be stable (ie, unchanged > 3 months)
• Have internet access (can be via smartphone or computer). If neither device is available, the study can loan participants a Wi-Fi enabled device.

Exclusion Criteria:

• Do not reside in the United States
• Do not speak English
• Already fasting >12 hours per 24-hour day
• On insulin or GLP-1 agonist
• Diagnosis of type 1 diabetes mellitus
• Enrolled in a formal weight management program or other weight loss trial
• History of an eating disorder