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ASCENT Intervention for Brain Tumor Patients

ASCENT Intervention for Brain Tumor Patients

Recruiting
18 years and older
All
Phase N/A

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Overview

The goal of this study is to refine and test a psychosocial intervention called ASCENT (ACT-based Supportive intervention for patients with CENTral nervous system tumors). This intervention was developed to help patients after being diagnosed with a brain tumor. The main question this study aims to answer is whether this intervention is feasible (i.e., possible to carry out) and acceptable (i.e., considered helpful) to patients. Participants will be asked to take part in 6 coaching sessions and complete short surveys at four different time points. Some participants will be asked to share feedback via interviews.

Description

This study will examine the feasibility and acceptability of a novel, population-specific intervention designed to help patients with newly diagnosed malignant brain tumors cope with their illness.

This project is currently recruiting participants for intervention refinement activities in preparation for the pilot RCT. For intervention refinement, we are enrolling 15 stakeholders and 10 open pilot participants to gather feedback about the intervention to improve it prior to commencing the randomized controlled trial. The stakeholder feedback and open pilot refinement phase of the study is critical for intervention refinement for the RCT. The investigators will then evaluate the feasibility and acceptability of the refined ASCENT intervention versus usual care in this pilot randomized controlled trial (n=100). The investigators will also estimate preliminary effects of ASCENT on psychological and behavioral outcomes.

Eligibility

Inclusion Criteria:

  • Age ≥ 18
  • Massachusetts General Hospital Cancer Center Patient
  • Within 6 months of diagnosis of malignant primary Central Nervous System (CNS) tumor
  • English speaking

Exclusion Criteria:

  • Inability to provide informed consent as assessed by the study team (e.g., due to severe cognitive impairment/dementia)
  • Moderate to severe receptive aphasia (Quick Aphasia Battery sentence comprehension subscale < 8)
  • Current or imminent hospice enrollment

Study details
    Malignant Brain Tumor
    Glioma
    Coping Skills
    Distress
    Emotional

NCT06099743

Massachusetts General Hospital

15 October 2025

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