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Glucagon-like Peptide-1 Receptor Agnoists for the Assessment of Adrenal Function

Glucagon-like Peptide-1 Receptor Agnoists for the Assessment of Adrenal Function

Recruiting
18-60 years
Male
Phase N/A
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Overview

This study aims to investigate the effects of a single dose of the glucagon-like 1 receptor agonist semaglutdie/Rybelsus on the hypothalamo-pituitary-adrenal axis, thus cortisol levels and other stresshormones in healthy males.

Eligibility

Inclusion Criteria:

  • Healthy male volunteers aged 18-60 years
  • BMI 18.5-30 kg/m2
  • No regular medication

Exclusion Criteria:

  • participation in a trial with investigational drugs within 30 days
  • vigorous physical exercise within 24 hours before the study participation
  • alcohol intake within 24 hours before the study participation
  • a history of intake of glucocorticoids or GLP-1 RA within the last 8 weeks.
  • Known allergy towards GLP-1 RA

Study details
    Healthy Volunteer Study
    HPA
    Cortisol Deficiency
    Adrenal Insufficiency

NCT06608433

University Hospital, Basel, Switzerland

21 October 2025

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