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Periodization Resistance Training on Quality of Life in Females With Hypothyroidism

Periodization Resistance Training on Quality of Life in Females With Hypothyroidism

Recruiting
35-45 years
Female
Phase N/A

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Overview

This study will be conducted to compare between the effect of nonlinear and linear periodized training on quality of life in females with hypothyroidism.

Description

Worldwide, the incidence of individuals with thyroid dysfunction is increasing and represents approximately 30-40% of the patients seen in an endocrine clinic; thus, it is one of the leading endocrine disorders.The undiagnosed thyroid dysfunction especially subclinical and clinical hypothyroidism may increase cardiovascular risk factors.

The prevalence of hypothyroidism depends on many factors, such as age, sex and geographical factors. It's also a diet related disorder and it's usually seen when the daily intake of iodine falls below 25μg.

Hypothyroidism tends to affect women more often than men and can manifest at any age, typically observed between 40 and 70 years. No specific racial predilection has been identified in studies regarding this condition. regular exercise can improve quality of life in patients with subclinical hypothyroidism by increasing physical activity level/fitness and reducing the signs and symptoms of the disease. Exercise may therefore potentiate the effectiveness of levothyroxine and help hypothyroid individuals improve their quality of life.

Periodization of resistance training or planned changes in training volume and intensity are used to maximize strength and fitness gains. The most common of periodized resistance training plans is linear also termed classic or strength/power periodization and nonlinear periodization. The biggest difference between these two types of training plans is with nonlinear periodization changes in training volume and intensity are made more frequently. The most common type of nonlinear periodization is daily nonlinear periodization where substantial changes in training intensity and volume are made from one training session to the next training session.

So, this study will be conducted to compare between the effect of non linear and linear periodized resistance training on quality of life in females with hypothyroidism.

Eligibility

Inclusion Criteria:

  • Be controlled hypothyroidism (TSH level within 0.5 - 4.5 mU/L)
  • Be ranged from 35 to 45 years
  • Female patients
  • Body Mass Index 30-34.9 kg/m2 .
  • triglyceride-glucose (TyG) index > 4.5

Exclusion Criteria:

  • history of pulmonary disease
  • Patients with uncontrolled coronary or cerebrovascular disease
  • Those who underwent musculoskeletal surgery within the previous year
  • Recent history of lower and upper limb fracture , hip and shoulder dislocation.
  • Cognitive impaired patients
  • Patients with history of epilepsy
  • Patients who participating in any other exercise program

Study details
    Hypothyroidism

NCT06757712

Cairo University

21 October 2025

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