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A Study to Evaluate Lenti-HPV-07 Immunotherapy Against HPV+ Cervical or Oropharyngeal Cancer

A Study to Evaluate Lenti-HPV-07 Immunotherapy Against HPV+ Cervical or Oropharyngeal Cancer

Recruiting
18 years and older
All
Phase 1/2
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Overview

The goal of this clinical trial is to learn about the safety and efficacy of a potential new treatment called Lenti-HPV-07 in patients with a cancer induced by Human Papilloma Virus (HPV).

The main questions aim to answer are:

  • Is Lenti-HPV-07 safe?
  • Does Lenti-HPV-07 induce an immune response?

Participants will be assigned to a group based on their cancer type

  • either study drug group A: recurrent and/or metastatic cancer
  • or study drug group B: newly diagnosed with locally advanced cancer

After they finish the study treatment, they will be followed for up to 1 year. Follow-up visits will occur via clinic visits or phone calls 4 weeks after the last study treatment and then quarterly for up to 1 year.

Eligibility

Inclusion Criteria:

  • histologically confirmed invasive HPV-related oropharyngeal or cervical cancer
  • ECOG performance status of 0 or 1
  • adequate hepatic, renal, pulmonary, and bone marrow/hematological function

Exclusion Criteria:

  • with seropositivity for HIV, active hepatitis C virus (HCV) infection, or hepatitis B (HBV) infection

Study details
    HPV-Related Cervical Carcinoma
    HPV Positive Oropharyngeal Squamous Cell Carcinoma

NCT06319963

Theravectys S.A.

15 October 2025

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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