Overview
AIM: to compare the sensitivity of SV2A PET and volumetric MRI to detect longitudinal striatal changes in premanifest HD.
DESIGN: The investigators will include late premanifest HD mutations carriers and matched healthy controls. All subjects will undergo a clinical examination, with comprehensive assessment of motor and non-motor symptoms, and imaging evaluation consisting of 18F-SynVesT-1 PET and volumetric MRI at baseline and after 2 years.
Eligibility
Inclusion Criteria:
- Age 20-75 years inclusive.
- Capacity to understand the informed consent form.
- HD mutation carriers:
- HTT (CAG)n ≥ 40
- HD-ISS < 2
- CAP100 score > 70
Exclusion Criteria:
- neuropsychiatric diseases (other than HD for HD mutation carriers)
- major internal medical diseases
- white matter lesion load on FLAIR Fazekas score 2 or higher or other relevant MRI abnormalities
- history of alcohol abuse or current alcohol abuse (chronic use of more than 15 units per week) or drug abuse
- contraindications for MR
- pregnancy
- previous participation in other research studies involving ionizing radiation with more than 1 mSv in the previous 12 months.