Overview
Two combination interventions (HIV Case Finding Intervention and HIV Treatment Intervention), each with mHealth and Peer Navigation components, will be evaluated in two 48-week parallel hybrid effectiveness/implementation trials among youth aged 15-24 in Nigeria.
Description
Two combination interventions, each with mHealth and Peer Navigation components, will be evaluated in two 48-week parallel hybrid effectiveness/implementation trials among youth aged 15-24 in Nigeria:
- HIV Case Finding Intervention: single arm trial of an HIV case finding and linkage to care intervention targeting young men at risk of HIV infection (n = 6000), particularly young men who have sex with men (YMSM) in Akwa Ibom, Benue, Enugu, Kano, Taraba, and Lagos states who complete HIV testing.
Objectives: To determine the effectiveness of the intervention to:
- identify youth living with HIV, particularly YMSM and
- link those who test HIV-positive to HIV care
- pre-exposure prophylaxis (PrEP) initiation (uptake) among those who test HIV-negative. 2. HIV Treatment Intervention: randomized controlled trial of a medication adherence and viral suppression intervention among youth newly diagnosed with HIV and initiating antiretroviral therapy (ART) for the first time (n = 600) at the participating clinical sites.
Objectives: To determine the effectiveness of the intervention on
- viral suppression and
- adherence to ART
- success of implementation in the target populations
Eligibility
Inclusion Criteria:
HIV Case Finding Intervention:
- Aged 15 to 24
- Male birth sex of any current gender identity
- Understand basic English, Yoruba, Hausa, Igbo or Pidgin English For the PrEP component, must also be HIV-negative
HIV Treatment Intervention:
- Aged 15 to 24
- HIV seropositive
- Initiating ART for the first time at a Clinical Research Performance Site (CRPS) clinic or satellite clinic
- Understand basic English, Yoruba, Hausa, Igbo or Pidgin English
- Intention to remain a CRPS patient during follow-up
Exclusion Criteria:
- Unable to provide consent
- No parental permission if aged 15 and not emancipated