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Effect of Genetic Polymorphism on Capecitabine-Induced Toxicity in Egyptian Cancer Patients

Effect of Genetic Polymorphism on Capecitabine-Induced Toxicity in Egyptian Cancer Patients

Recruiting
18 years and older
All
Phase N/A
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Overview

The goal of this observational study is to study the effect of a single nucleotide polymorphism in the CES1 gene (rs2244613) on capecitabine-induced toxicity in Egyptian cancer patients. This study will help in understanding the interindividual variability in the CES1 gene and the effect of a single nucleotide polymorphism in this gene (rs2244613) on capecitabine-induced toxicity in participants already taking capecitabine-based chemotherapy as part of their regular medical care.

Eligibility

Inclusion Criteria:

  • Patients with breast or colorectal cancer receiving capecitabine-based chemotherapy
  • Age > 18 years
  • ECOG PS 0-2.

Exclusion Criteria:

  • Patients treated with irinotecan
  • Lack of physical integrity of the upper gastrointestinal tract
  • Patients with malabsorption syndrome
  • Patients having inability to take oral medication
  • Patients with poor performance status
  • Patients with chronic diarrhea as ulcerative colitis or Crohn's disease

Study details
    Colorectal Cancer
    Breast Cancer

NCT06765252

Ain Shams University

21 October 2025

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