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SBU-RESET: RElaxation, Stress Reduction and Epigenetics Trial in Cancer Survivors

SBU-RESET: RElaxation, Stress Reduction and Epigenetics Trial in Cancer Survivors

Recruiting
18 years and older
All
Phase N/A

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Overview

Cancer survivors can experience health issues that cause chronic illness and lower quality of life. Yoga is a well-known holistic approach to health and overall well-being. Mindfulness has many benefits, including improved focus and less stress. This study aims to evaluate if yoga and/or mindfulness has a positive effect on cancer survivors social, emotional and physical well-being as well as their epigenetics. Epigenetics is how the environment can effect your genes; not by changing our DNA, but by turning genes on or off.

Description

Randomized interventional pilot study to evaluate whether a mind-body intervention (Stress Management and Resiliency Training (SMART) or (oncology-informed yoga) influences patient-reported Quality of life (QoL) outcomes (physical/social/emotional/ functional well-being and symptom burden) in Lung Colon, and Non-Hodgkin's lymphoma (NHL) survivors. A secondary (exploratory) aim is to evaluate whether these mind-body interventions impact epigenetics.

Eligibility

Inclusion Criteria:

  • Adults over 18 years old
  • Primary diagnosis: Lung Cancer, Colon Cancer and Non-Hodgkin's lymphoma (NHL)
  • Six months post cancer-directed treatment (chemotherapy, targeted and immunotherapy). Patients with active disease (e.g. metastatic colorectal cancer) who are not receiving any cancer-directed treatment are eligible.
  • Able to provide a saliva sample
  • Gives informed consent and agrees to be randomly assigned
  • Able to complete the questionnaire(s) in English.

Exclusion Criteria:

  • Adults with primary anal and/or primary rectal cancer.
  • Adult cancer survivors who are currently on an active treatment regimen.
  • Oral or any pathological conditions that can limit the ability to produce saliva.
  • Unable to participate in full length study period and follow up thereafter.
  • Is pregnant or plan to become pregnant during the study period.
  • Currently practicing yoga or SMART
  • Those on corticosteroid therapy.
  • Documented fall or syncope within the last 6 months

Study details
    Lung Adenocarcinoma
    Lung Adenocarcinoma Metastatic
    Lung Adenocarcinoma Stage III
    Lung Adenocarcinoma Stage IIIB/IV
    Lung Adenocarcinoma Stage IV
    Lung Adenocarcinoma Stage I
    Lung Adenocarcinoma Stage II
    NHL
    NHL - Non-Hodgkin&Amp;#39;s Lymphoma
    Lung Cancer (Diagnosis)
    Colon Cancer

NCT07161713

Barbara Nemesure

15 October 2025

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