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The Effects of Dexmedetomidine on Postoperative Cognitive Function in Open Heart Surgery

The Effects of Dexmedetomidine on Postoperative Cognitive Function in Open Heart Surgery

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Overview

To assess the impact of Dexmedetomidine on postoperative cognitive function and serum Neuron Specific Enolase levels as an indicator of neuronal injury in patients undergoing open heart surgery

Eligibility

Inclusion Criteria:

  • Patients of both sexes undergoing elective open-heart surgery

Exclusion Criteria:

  • Patients with a history of neurological disorders, severe renal or liver dysfunction, or contraindications to Dexmedetomidine as in patients with known QT prolongation, a history of other arrhythmias, symptomatic bradycardia, hypokalemia, or hypomagnesemia, and in patients receiving other drugs known to prolong the QT interval.

Patients with cognitive impairment, mental and psychological illness and chronic alcoholics, drug addicts, abuse of psychotropic substances, illiterate education

Study details
    Open Heart Sugery
    Neuronal Damage

NCT06655025

Sohag University

21 October 2025

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