Overview
Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking. Split-belt walking will be performed under DBS ON and DBS OFF conditions, while off-medication.
Description
We will test the hypotheses that DBS can facilitate split-belt walking adaptation with DBS ON compared with DBS OFF.
Eligibility
Inclusion Criteria:
- consensus diagnosis of idiopathic PD by fellowship trained movement disorders neurologists at the Normal Fixel Institute of Neurological Diseases;
- chronically stable DBS, defined as having had DBS for at least 6 months in duration with optimized DBS settings;
- Age between 18 - 80 years old per the FDA data sheet for PD DBS;
- no dementia according to the clinical diagnostic criteria for PD dementia;
- ambulatory without the use of walking aids, or another person's assistance.
Exclusion Criteria:
- other previous neurological surgery;
- suspicion of other neurologic diagnoses such as atypical parkinsonism, or Alzheimer's disease.