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The Effects of Prayer on Pain Thresholds and Scores of Anxiety and Depression in Patients With Migraine and Control

The Effects of Prayer on Pain Thresholds and Scores of Anxiety and Depression in Patients With Migraine and Control

Recruiting
18-60 years
All
Phase N/A

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Overview

The objective of this randomized single-blind crossover study is to evaluate the effect of prayer compared to the practice of reading a text (control) on the pressure pain threshold in individuals with and without migraine. The main topics it aims to answer are:

  • To analyze the relationship between individuals' spirituality, pain thresholds, and anxiety and depression scores.
  • To evaluate the effects of different aspects of prayer (thanksgiving, adoration, confession, meditative, and petitionary) on cephalic pain thresholds in individuals with and without migraines.

Migraine group: 55 participants. Non-migraine group: 55 participants. Number of participants in total: 110.

Description

Pressure pain thresholds (PPT) represent each person's sensitivity, where the pressure is gradually increased, and participants report when the applied pressure changes from a sensation of pressure to a sensation of pressure and pain. The NOD device is equipped with a digital algometry function, providing reliable quantification of the pressure pain threshold for each individual. For proper use, a 1 cm² adapter will be attached to the front of the device. The tip of this adapter will be positioned perpendicularly to the anatomical structures to be assessed: the temporal region, frontal region, occipital nerve, and vertex. Pain threshold, defined as the minimum pressure required to provoke pain, will be measured in Kg/cm².

Eligibility

Inclusion Criteria:

  • Diagnosis of chronic or episodic migraine.
  • Feeling comfortable performing a known prayer.

Exclusion Criteria:

  • Severe acute circulatory disorders
  • Decompensated diabetes mellitus
  • Cognitive weaknesses that prevent the patient from understanding and carrying out the study procedures.

Study details
    Migraine

NCT07143461

University of Sao Paulo

15 October 2025

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