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A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia

A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia

Recruiting
18-65 years
All
Phase 2
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Overview

This study is a long-term extension (LTE) of the parent Study ORX750 0201, and will provide long-term open-label safety, tolerability, and efficacy of ORX750 in participants with narcolepsy type 1 (NT1), narcolepsy type 2 (NT2), and idiopathic hypersomnia (IH).

Eligibility

Inclusion Criteria:

  • Diagnosis of narcolepsy (NT1 or NT2) or IH who was eligible for and completed the full treatment period in the eligible parent study ORX750-0201 (CRYSTAL-1)
  • Is willing and able to adhere to additional protocol requirements

Exclusion Criteria:

  • Development of any new disease/disorder that in the opinion of the investigator would make the participant unable to continue the study
  • Unable to refrain from excluded medications, including those used for treatment of narcolepsy or idiopathic hypersomnia

Study details
    Narcolepsy Type 1
    Narcolepsy Type 2
    Idiopathic Hypersomnia

NCT07096674

Centessa Pharmaceuticals (UK) Limited

15 October 2025

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