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Orexin Gene in Anorexia Nervosa

Orexin Gene in Anorexia Nervosa

Recruiting
18 years and older
Female
Phase N/A
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Overview

The objectives of this study will be to determine the methylation of the promoter of the Orexin A (OX-A) and B (OX-B) genes in young women (> 18 years) with Anorexia Nervosa (AN), compared with a control group; and to evaluate the relationship of promoter methylation of the genes for OX-A and OX-B with the severity of the eating disorder, psychiatric comorbidities (in particular, depression), and sleep quality.

Eligibility

Patients with Anorexia Nervosa:

Inclusion Criteria:

  • Female sex
  • Age 18 years and older
  • Anorexia Nervosa
  • Hospitalized at the Division of Eating and Nutrition Disorders, Istituto Auxologico Italiano, IRCCS, Piancavallo, Italy

Exclusion Criteria:

  • Absence of signed informed consent

Control group:

Inclusion Criteria:

  • Female sex
  • Age 18 years and older
  • Body Mass Index between 18.5 and 24.9 kg/m2

Exclusion Criteria:

  • Absence of signed informed consent
  • Presence of any physical and mental pathology

Study details
    Anorexia Nervosa

NCT06800898

Istituto Auxologico Italiano

15 October 2025

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