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A Follow-on Study for Second-Eye Treatment for Participants Previously Treated With Gene Therapy for X-Linked Retinitis Pigmentosa (XLRP)

A Follow-on Study for Second-Eye Treatment for Participants Previously Treated With Gene Therapy for X-Linked Retinitis Pigmentosa (XLRP)

Recruiting
5 years and older
Male
Phase 2
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Overview

The purpose of this study is to assess the safety and tolerability of subretinal delivery of Adeno-associated Virus Vector (AAV5 hRKp.RPGR) gene therapy in adults and children with X-linked retinitis pigmentosa.

Eligibility

Inclusion Criteria:

  • Have been treated with AAV5-hRKp.RPGR in study MGT009 and have completed or is currently enrolled in Study MGT010
  • Must sign an informed consent form indicating that they understand the purpose and procedures of the study and is willing to participate in the study
  • Willing to adhere to the protocol and long-term follow-up

Exclusion Criteria:

  • There are no specific exclusion criteria to enroll in this study

Study details
    X-Linked Retinitis Pigmentosa

NCT06646289

Janssen Research & Development, LLC

15 October 2025

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