Overview
Major objectives To evaluate the efficacy of lparomlimab and Tuvonralimab injection (QL1706, an Anti-PD-1/ CTLA-4 Combined Antibody) in combination with TACE and lenvatinib as second-line therapy in patients with unresectable intermediate-to-advanced hepatocellular carcinoma.
Description
This single-arm, single-center clinical study aims to evaluate the efficacy and safety of lparomlimab and Tuvonralimab injection (QL1706, an Anti-PD-1/ CTLA-4 Combined Antibody) in combination with TACE and lenvatinib as second-line therapy in patients with unresectable intermediate-to-advanced hepatocellular carcinoma. This study consists of three phases: screening, treatment, and follow-up. Efficacy evaluation and safety monitoring should be performed throughout the study.
Eligibility
Inclusion Criteria:
- Comprehension and voluntary signing of the study's informed consent form;
- Age ≥18 years, any gender;
- Histologically or clinically confirmed hepatocellular carcinoma;
- Documented failure or intolerance to first-line therapy with PD-1/PD-L1 inhibitor plus bevacizumab;
- ECOG performance status 0-2;
- Child-Pugh class A or class B (score ≤7) without hepatic encephalopathy history;
- Life expectancy ≥3 months;
- At least one measurable target lesion confirmed by screening imaging per RECIST v1.1;
- Adequate organ and bone marrow function within 7 days prior to initial study treatment;
- Active HBV/HCV infection requires ongoing antiviral therapy; k.Fertile patients must
use highly effective contraception with partners during treatment and ≥180 days
post-last dose.
2.Exclusion Criteria:
- Inability to comply with the study protocol or procedures;
- Histologically/cytologically confirmed fibrolamellar HCC, sarcomatoid HCC, cholangiocarcinoma, or mixed hepatocellular-cholangiocarcinoma;
- History of liver transplantation or planned transplantation;
- Presence of central nervous system metastases and/or leptomeningeal carcinomatosis;
- Baseline imaging showing Vp4 portal vein tumor thrombosis;
- Hypersensitivity to any study drug components or history of severe allergic reactions;
- Concurrent HBV and HCV co-infection;
- Clinically significant ascites requiring intervention during screening;
- Concurrent use of other investigational drugs or participation in another clinical trial within 4 weeks prior to enrollment;
- Esophageal/gastric variceal bleeding due to portal hypertension within 6 months before treatment initiation, or high-risk varices on endoscopy within 3 months;
- Current interstitial lung disease (ILD), history of steroid-required ILD, or other pulmonary fibrosis/organizing pneumonia affecting immune-related pulmonary toxicity assessment;
- Uncontrolled hypertension (SBP≥160 mmHg and/or DBP≥100 mmHg despite medication), coronary artery disease, arrhythmias, or heart failure (NYHA Class ≥II);
- Uncontrolled clinically significant infections requiring IV antimicrobial therapy;
- Proteinuria ≥2+ (≥1.0g/24h);
- History of hemorrhagic tendency regardless of severity within 2 months prior to enrollment;
- Arterial/venous thromboembolic events within 12 months before treatment initiation (e.g., cerebrovascular accident including TIA);
- Acute myocardial infarction, acute coronary syndrome, or CABG within 6 months before treatment;
- Unhealed fractures or chronic non-healing wounds;
- Coagulopathy, bleeding diathesis, or current therapeutic anticoagulation;
- Other malignancies within 5 years except curatively resected basal/squamous cell skin carcinoma or cervical carcinoma in situ;
- Active autoimmune disease or autoimmune disease history requiring immunosuppression within 4 weeks prior to enrollment;
- Prior allogeneic bone marrow or solid organ transplantation;
- Investigator assessment of ineligibility based on medical/safety reasons.