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68Ga-NY104 PET/CT Guided Radiation Therapy in CcRCC.

68Ga-NY104 PET/CT Guided Radiation Therapy in CcRCC.

Recruiting
18 years and older
All
Phase 2
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Overview

Radiation therapy (RT) is an effective treatment for patients with advanced-stage clear cell renal cell carcinoma (ccRCC). Current evidence has shown promising outcomes combining radiation therapy and standard systemic therapy in patients with metastatic/recurrent ccRCC. CAIX is a highly sensitive and specific biomarker expressed on ccRCC and in previous studies the investigators have shown excellent diagnostic efficacy of 68Ga-NY104, a CAIX-targeted PET tracer, in patients with metastatic ccRCC. In this study, the investigators aim to investigate the effect of 68Ga-NY104, and 18F-FDG PET/CT guided RT combining standard systemic therapy in patients with metastatic ccRCC.

Eligibility

Inclusion Criteria:

  • Age ≥ 18 years old
  • Histologically or cytologically confirmed clear cell renal cell carcinoma
  • Eligible for radiation therapy: no more than 10 lesions in total
  • Expected survival: over 3 months
  • ECOG: 0 or 1
  • Sufficient organ function
  • Written informed consent

Exclusion Criteria:

  • Brain metastasis/carcinomatous meningitis
  • Other malignant tumors that are not controlled within 5 years, except for non-metastatic low-risk prostate cancer.
  • Pregnant or breastfeeding.
  • Active infection.

Study details
    Clear Cell Renal Cell Carcinoma

NCT06613269

Peking Union Medical College Hospital

15 October 2025

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