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ABG+/GarlACE Effects on Cardiovascular Risk Factors in Subjects With Grade I Hypertension

ABG+/GarlACE Effects on Cardiovascular Risk Factors in Subjects With Grade I Hypertension

Recruiting
18-75 years
All
Phase N/A
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Overview

The goal of this clinical trial is to evaluate the dose response effect on cardiovascular disease risk factors of a Black Garlic Extract in subjects with Grade I Hypertension. The main questions it aims to answer are:

  • If the reduction in blood pressure (systolic and diastolic) is in a dose-response manner
  • If the changes in lipid profile are in a dose-response manner

Participants will be randomly assign to a low dose (250 mg/day), high dose (600 mg/day) or placebo of a standardized Garlic Extract (ABG+/GarlACE) during 12 weeks

Eligibility

Inclusion Criteria:

  • Men and women with Grade I Hypertension (systolic blood pressure between 130 and 139 mmHg; and diastolic blood pressure between 80 to 89 mmHg) without taking any antihypertensive drug

Exclusion Criteria:

  • Acute or chronic kidney disease including dyslipidemia due to nephrotic syndrome.- -
  • Hypothyroidism
  • Having previously suffered a myocardial infarction or stroke
  • Pharmacological treatment with insulin, sulfonylureas, protease inhibitors
  • Chronic gastrointestinal disease
  • Pregnancy or intention to become pregnant during the study period.
  • Breastfeeding
  • Allergy or intolerance to garlic
  • High alcohol consumption (>14 units per week)
  • Smokers

Study details
    Hypertension

NCT06264622

Universitat de Lleida

21 October 2025

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