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Lanadelumab in Long-term Prophylaxis of Acquired Angioedema

Lanadelumab in Long-term Prophylaxis of Acquired Angioedema

Recruiting
18 years and older
All
Phase 4
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

use of lanadelumab in patients with acquired angioedema

Eligibility

Inclusion Criteria:

  • A diagnosis of AAE with recurrent attacks without urticaria (decreased C1INH functional, quantitative levels, decreased C4 and decreased C1q levels, no family history of angioedema), presence of anti-C1INH antibody and/or paraproteinemia (e.g. monoclonal gammopathy of unknown significance)
  • historical attack rate of >= on attack per month prior to starting tranexamic acid (TAA)

Exclusion Criteria:

  • History of anaphylaxis or hypersensitivity to biologics
  • History of major systemic disease not well controlled in opinion of the PI
  • Women who are pregnant or breast feeding
  • Concurrent participation in other clinical trials
  • HAE Type 1 or 2 and normal complement HAE

Study details
    Angioedema

NCT06818474

Bernstein Clinical Research Center

15 October 2025

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