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Treating Psychosocial Distress in Glaucoma

Treating Psychosocial Distress in Glaucoma

Recruiting
18 years and older
All
Phase N/A

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Overview

In this study, using three phases, the investigators will use an iterative development approach to refine a behavioral intervention for managing concomitant psychosocial distress in glaucoma. Phase 1: The investigators will begin by developing a baseline intervention using strategies from Acceptance and Commitment Therapy (ACT), and delivered using a mobile application. Phase 2: The investigators will refine the baseline intervention for glaucoma patients using qualitative interviews conducted with primary open-angle glaucoma (POAG) patients with psychosocial distress (N=20), and health professionals (N=5). Phase 3: Finally, the investigators will measure acceptability and feasibility of the refined intervention through a single-armed pilot study (N=25). The investigators hypothesize that the refined intervention will yield an acceptable and feasible intervention in a POAG patient population, setting the stage for a future efficacy study.

Eligibility

Inclusion Criteria

  • diagnosed with mild, moderate, or severe chronic glaucoma (e.g., POAG),
  • had a visual field within the past year at the main Duke Eye Center,
  • been prescribed pressure lowering eye drop medication,
  • at least mild distress (based on PHQ-4),
  • 18 years old,
  • able to understand, speak, and read English, and
  • be able to provide informed consent.

Exclusion Criteria

  • diagnosed with borderline glaucoma or as a glaucoma suspect,
  • had a glaucoma surgery in past month (e.g., trabeculectomy, glaucoma drainage device/tube),
  • visual acuity of worse than 20/70 in the better seeing eye,
  • diagnosed with a major medical conditions (e.g., cancer, or another visual disorder, like macular degeneration),
  • diagnosed with a psychiatric conditions (e.g., schizophrenia, bipolar disorder), and
  • reported or suspected cognitive impairment indicated by provider or chart review.

Study details
    Glaucoma
    Primary Open Angle
    Distress
    Emotional
    Anxiety
    Depression

NCT06053307

Duke University

15 October 2025

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