Overview

The goal of this observational study is to learn about the Effects of neoadjuvant therapy with carboplatin, paclitaxel combined with anti-PD-1 drugs on cognitive function in patients with resectable head and neck squamous cell carcinoma: a prospective cohort study

Eligibility

Inclusion Criteria:

• 1: The patient was diagnosed with head and neck squamous cell carcinoma (stage I-IVA), without treatment, and planned to undergo only surgical treatment or surgical treatment + chemotherapy and immunotherapy. 2: Can speak Chinese and have certain reading and writing skills 3: Healthy group: Dental inpatients with non-oral cancer, no history of neurological diseases, and no previous history of malignant tumors

Exclusion Criteria:

• 1: Brain tumor, brain injury, or stroke at baseline or during follow-up 2: A history of stroke or a medical condition that puts you at high risk for future dementia or recurrence 3: Active mental illness or active narcotic drug use, including using alcohol more than 4 times per day or more than 4 times per week 4: Neurocognitive diseases that affect cognitive function, such as Parkinson's disease or Alzheimer's disease 5: History of drug-associated encephalopathy or brain infection 6: Patients who change their treatment plan during treatment 7: Patients who are currently taking or have taken antidepressants