Overview
Evaluating the Optimal Effective Dose and Safety of Conbercept in Treating Retinopathy of Prematurity (ROP)
Eligibility
Inclusion Criteria:
- Preterm infants with less than or equal to 2000 grams of birth weight or less than or equal to 32 weeks of gestational age
- Bilateral type 1 ROP with one of the following retinal findings in each eye
- Zone I, stage 1+, 2+, 3+/- disease, or
- Zone II, stage 2+, 3+, disease, or
- A-ROP
Exclusion Criteria:
- Preterm infants with stage 4 or 5 ROP in one or both eyes
- Have received any previous surgical or nonsurgical treatment for ROP, including laser photocoagulation, anti-VEGF therapy, vitrectomy
- Have been previously exposed to any intravitreal or systemic anti-VEGF agent (either the patient or the mother during this child's pregnancy)
- Have used (either the patient or the mother) other investigational drugs as part of another clinical study (other than vitamins and minerals) within 30 days or within 5 half-lives of the other investigational drug, whichever is longer
- Have active ocular infection within 5 days before or on the day of first investigational treatment
- Have a history of hypersensitivity (either the patient or the mother) to any of the investigational treatments or to drugs of similar chemical classes
- Have any contraindication for intravitreal injection clearly stated in the instructions
- Have any ocular structural abnormality that may affect efficacy assessments
- Have a history of any other congenital or systemic conditions that are assessed by the investigator to have a significant risk of severe impact on visual function
- Have any other medical conditions or clinically significant comorbidities or personal circumstances that are assessed by the investigator to have a clinically relevant impact on study participation, any of the study procedures, or on efficacy assessments