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Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise

Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise

Recruiting
18-35 years
All
Phase N/A
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Overview

The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral arteries during a maximal exercise test at low altitude and high altitude.

Eligibility

Inclusion Criteria:

  • Must be a member of the research expedition team travelling to the Barcroft Research Station in White Mountain California

Exclusion Criteria:

  • BMI > 30
  • No prescribed medications (oral contraceptives excluded)
  • History of smoking
  • Currently following a ketogenic diet or consuming exogenous ketogenic supplements
  • History of heart, lung, blood vessel, or kidney disease
  • Currently pregnant

Study details
    High Altitude Hypoxia
    Exercise

NCT07063732

McMaster University

21 October 2025

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