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Neutralizing Power of Serum Antibodies - 2

Neutralizing Power of Serum Antibodies - 2

Recruiting
18 years and older
All
Phase N/A
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Overview

Severe forms of COVID-19 and Monkeypox affect immunocompromised and comorbid individuals. Vaccination and monoclonal antibody therapies induce neutralizing antibodies. This neutralizing power is recognized as a correlate of protection against a new infection. This study aims to describe the neutralizing power of serum and nasal antibodies over time, in relation to SARS-CoV-2 and MPXV vaccines or treatments received.

Description

This is a monocentric, longitudinal, descriptive study aiming to measure and describe the evolution of the humoral immune response (serum and nasal) to SARS-CoV-2 and MPXV, following any vaccination or administration of monoclonal antibodies. Samples are collected over a maximum 60-month period per participant to assess the durability of neutralizing activity.

Eligibility

Inclusion Criteria:

  • Adults (≥18 years)
  • Patients receiving or scheduled to receive anti-SARS-CoV-2 and/or anti-MPXV vaccines or monoclonal antibodies
  • Patients have provided written informed consent

Exclusion Criteria:

  • Persons under guardianship or curatorship
  • Persons under legal protection,
  • Persons persons deprived of liberty
  • Persons not affiliated to a social security scheme
  • Pregnant or breastfeeding women

Study details
    COVID-19
    SARS-CoV-2 Viraemia
    Monkey Pox
    Vaccination
    Serum
    Mucosal Immunity

NCT07085611

Centre Hospitalier Régional d'Orléans

15 October 2025

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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