Overview
To determine the clinical utility of serum cystatin C in early detection of acute kidney injury (AKI).
Description
The primary objective of this study is to evaluate the clinical utility of Cystatin C in early detection of contrast-induced AKI.
To evaluate the effect of patient characteristics in the Cystatin C based GFR estimation in comparison to Cr based estimation.
Eligibility
Inclusion Criteria:
- Subjects ages 18 years and above
- Inpatients with CKD (Figure 1)
- Order for CT imaging study or coronary angiography with isohexol Omnipaque) contrast media.
- Pre and post contrast available
- All races and ethnicity of patients are eligible. We expect to analyze approximately equal number of men and women in this study.
Exclusion Criteria:
- Preexisting dialysis
- Patients under the age of 18 years
- Pregnancy
- Incarcerated individuals
- Patients with impaired cognition and unable to follow consent procedures
- Recent exposure to CM (within 2 days before/after procedure)
- Cardiac shock
- Medications that affect biomarkers, including corticosteroids, lfamethoxazoletrimethoprim