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The Effect of Acute Exogenous Oral Ketone Supplementation on Immune Cells Function and Immune Cells Histone Β-hydroxybutyrylation

The Effect of Acute Exogenous Oral Ketone Supplementation on Immune Cells Function and Immune Cells Histone Β-hydroxybutyrylation

Recruiting
19 years and older
All
Phase N/A
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Overview

To conduct a single-arm pilot study to determine how acute ingestion of an exogenous ketone monoester supplement alters the histone lysine β-hydroxybutyrylation and immune function in healthy human monocytes and lymphocytes.

Eligibility

Inclusion Criteria:

  • Over the age of 19
  • Able to fast overnight

Exclusion Criteria:

  • Being a competitive endurance athlete.
  • Following a ketogenic diet, low-calorie diet, periodic fasting regimen, or regularly consuming ketogenic supplements.
  • Being unable to travel to and from the university
  • Being pregnant.
  • Having been diagnosed with a chronic disorder of glucose or fat metabolism, including type 2 diabetes, chronic pancreatitis, or gallbladder disease
  • Being unable to read or communicate in English.

Study details
    Ketosis
    Metabolic
    Immune Functions
    Histone Deacetylase (HDAC) Activity

NCT06590623

University of British Columbia

21 October 2025

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