Overview
This study aims to evaluate the effect of increasing preoperative timing of single dexmedetomidine on the stress response of laryngoscopy and intubation.
Description
Maintaining hemodynamic stability during surgery is one of the most important tasks because good anesthesia increases the success rate of surgery and improves postoperative prognosis.
Dexmedetomidine, a potent α2-adrenoreceptor agonist, produces not only a sedative-hypnotic effect, but in situations involving cardiac risk, it also produces analgesic effects and an autonomic blocking effect, by acting on a single type of receptor.
Eligibility
Inclusion Criteria:
- Age from 18 to 65 years.
- Both sexes.
- American Society of Anesthesiology (ASA) physical status I-II.
Exclusion Criteria:
- Severe cardiovascular problems.
- Respiratory disorders.
- Diabetes.
- Hypertension.
- Obesity.
- Allergic reaction to study drugs.
- Patients on antihypertensive medication (α-methyldopa, clonidine, or other α2-adrenergic agonists)
- Medications that affect heart rate (HR) or blood pressure (BP).
- Pregnant.
- Currently breast-feeding women.
- History of sleep apnea.
- Those for emergency procedures.