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Radiofrequency Ablation for Management of Benign/Indeterminate Thyroid Nodules and Low Risk Papillary Thyroid Cancers

Radiofrequency Ablation for Management of Benign/Indeterminate Thyroid Nodules and Low Risk Papillary Thyroid Cancers

Recruiting
18 years and older
All
Phase N/A

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Overview

To track the outcomes of patients who have been treated with RFA and its long-term effectiveness, and to learn more about the quality of life of patients who have received RFA in this study.

Description

Primary Objectives

• To evaluate thyroid nodule volume changes over time in participants undergoing RFA as part of clinical care

Secondary Objectives

  • To establish the health-related quality of life among participants undergoing with ultrasound guided RFA.
  • To evaluate the sonographic features of thyroid nodules over time following ultrasound guided RFA.
  • To assess adverse events rates following ultrasound guided RFA.

Eligibility

Eligibility Criteria

  1. Participants scheduled to undergo ultrasound-guided RFA for the following conditions: benign thyroid nodules, indeterminate thyroid nodules, low-risk DTC, and recurrent PTC
  2. Participant is over 18 years and is either not a surgical candidate or has declined surgery.
  3. Capable and willing to provide written informed consent
  4. Participant has one of the following diagnoses:
    • Biopsy-proven benign thyroid nodules causing compressive and/or cosmetic symptoms who are requesting treatment,
    • Biopsy-proven indeterminate nodules (AUS or follicular neoplasm)
    • Papillary thyroid carcinoma (PTC) without metastasis
    • Locally recurrent thyroid cancer (< 2 cm).

Exclusion Criteria

  1. Participants meeting any of the following criteria will be excluded:
  2. Participants considered unsuitable for RFA by the treating physician

Study details
    Low Risk
    Papillary Thyroid Cancer
    Radiofrequency Ablation

NCT07140757

M.D. Anderson Cancer Center

15 October 2025

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