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Genicular Nerve Block for Knee Pain in the ED

Genicular Nerve Block for Knee Pain in the ED

Recruiting
18 years and older
All
Phase N/A

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Overview

Patient with atraumatic knee pain without a large knee effusion on x-ray will be randomized to receive either a genicular nerve block (GNB) or standard of care in the emergency department.

Eligibility

Inclusion Criteria:

  • Atraumatic knee pain
  • >17 years age
  • X-ray of the knee obtained in the ED
  • Initial pain score (numeric rating scale) 5-10

Exclusion Criteria:

  • Fracture or dislocation on x-ray
  • large knee joint effusion identified on x-ray
  • allergy or contraindication to local anesthetics
  • History of local anesthetic systemic toxicity after receiving local anesthetics
  • Pregnancy
  • Incarcerated
  • History of knee replacement of affected knee
  • Concern for septic joint
  • Overlying cellulitis
  • Hemodynamic instability
  • Altered mental status or inability to consent for procedure.

Study details
    Knee Pain

NCT07158736

University of Pennsylvania

15 October 2025

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