Overview
The traditional view holds that the natural course of cirrhosis is a unidirectional process, characterized by irreversible progression from the compensated stage to the decompensated stage, and is highly likely to develop further decompensation events or even death [1-2]. However, a growing body of evidence suggests that the natural course of cirrhosis is not always unidirectional - after the removal of the etiology, the structural and functional changes of the liver may be partially reversed [3]. This understanding has given rise to the concept of "liver recompensation," which has been standardized at the Baveno VII Consensus Conference. Notably, in a cohort of patients with alcohol-related cirrhosis, 18% achieved recompensation, which was significantly associated with a reduction of more than 90% in liver-related mortality [4]. In patients with hepatitis B-related cirrhosis, 6% achieved recompensation after treatment with nucleos(t)ide analogs, with a similar improvement in mortality [5].
Transjugular intrahepatic portosystemic shunt (TIPS) is a well-established therapy for complications related to portal hypertension, including gastroesophageal variceal bleeding, refractory ascites, and hepatic hydrothorax [6-7]. Compared with standard treatment, TIPS has been proven to reduce the incidence of further decompensation and improve transplant-free survival [8-9]. However, due to portal blood shunting, the risks of abnormal liver function and hepatic encephalopathy (HE) also increase [10]. It is worth noting that TIPS is not included in the definition of recompensation in the Baveno VII Consensus. Therefore, whether patients with cirrhosis who undergo TIPS treatment can achieve recompensation and which factors determine the probability of recompensation remain unknown. More importantly, the impact of recompensation on the risk of HCC development and mortality in TIPS patients has not been studied prospectively.
Eligibility
Inclusion Criteria:
- Age 18-80 years old;
- Diagnosed with decompensated cirrhosis (Diagnostic criteria: positive liver histology, or comprehensive assessment based on clinical symptoms, biochemical indicators, and imaging features);
- Intervenable aetiology (HBV/HCV/alcohol/MASLD).
Exclusion Criteria:
- Being in the compensated stage of cirrhosis when undergoing TIPS (without decompensation events such as ascites, hepatic encephalopathy, esophageal and gastric variceal bleeding, etc.);
- TIPS being used for the treatment of non-cirrhotic portal hypertension (such as idiopathic portal hypertension, Budd-Chiari syndrome, etc.);
- Existing hepatocellular carcinoma (HCC) before undergoing TIPS;
- Missing key clinical/biochemical data (unable to assess recompensation or outcome indicators).