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A Trial of Varenicline for E-cigarette Cessation

A Trial of Varenicline for E-cigarette Cessation

Recruiting
18 years and older
All
Phase 2
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Overview

This is randomized, placebo-controlled clinical trial in treatment-seeking adults who report regular e-cigarette use to test the hypothesis that varenicline is efficacious for quitting e-cigarettes.

Description

Participants will randomly be assigned to 12-weeks of varenicline (titrated to 2mg daily) or matching placebo plus brief cessation advice from a counselor and self-management resources. All participants will also complete research assessments every 3 weeks during treatment and a final follow-up visit at week 26.

The primary objective is to test the efficacy of varenicline vs. placebo on e-cigarette quit rates. We will also evaluate predictors and moderators of outcomes and explore changes in health biomarkers following e-cigarette cessation treatment.

Eligibility

Inclusion Criteria:

  • report daily use of an e-cigarette containing nicotine
  • live in Connecticut or South Carolina

Exclusion Criteria:

  • regular use of other tobacco products besides e-cigarettes
  • medical contraindications for varenicline use
  • current treatment for tobacco cessation
  • lack proficiency in English

Study details
    E-cigarette Use
    Vaping
    Nicotine Dependence

NCT07040566

Yale University

15 October 2025

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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