Overview
The purpose of this academic lead study is to explore the ideal stimulation strategies at Hand twelve jing-well points in patients with disorders of consciousness.
Eligibility
Inclusion Criteria:
- Age: 18-80 years old
- From 7 to 90 days since brain injury
- Diagnosed in VS/UWS or MCS as defined by at least two CRS-R assessments performed during the screening period
- Acquired cerebral damage of known etiology
- Intact hand skin
- Informed consent given by the legal surrogate
Exclusion Criteria:
- Patients who continuously receive sedative drugs and Na+ or Ca2+ channel blockers (e.g., carbamazepine) or NMDA receptor antagonists (e.g., dextromethorphan)
- History of previous serious、progressive neurological disorder prior to the brian injury
- Epilepsy and seizure
- Unstable vital signs or life-threatening comorbidities
- Active implant (e.g., cardiac pacemakers/defibrillators, deep brain stimulators, ventriculoperitoneal shunt, etc)
- Documented pregnancy