Overview
Pharmacokinetic Study of Topical Phenylephrine
Description
A Phase 1 Open-Label Study to Evaluate the Pharmacokinetics of Topical Phenylephrine Applied to the Scalp in Healthy Adult Females
Eligibility
Inclusion Criteria:
- Healthy females, age 18-55
- BMI: 18-30 kg/m²
- Fitzpatrick Skin Types I-IV (to standardize absorption risk)
- Scalp free from irritation, dermatologic disease, or damage
- Able to refrain from using other topical scalp products
Exclusion Criteria:
- History of cardiovascular disease, hypertension, or arrhythmia
- Scalp infections, wounds, or significant hair loss
- Recent use of medications that interfere with CYP enzymes or adrenergic systems
- Known sensitivity to phenylephrine or ethanol
- Positive drug screen or abnormal ECG at screening