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Study of DCC-2812 in Participants With Advanced Genitourinary Cancers

Study of DCC-2812 in Participants With Advanced Genitourinary Cancers

Recruiting
18 years and older
All
Phase 1
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Overview

This is a multicenter clinical trial to evaluate the safety and preliminary activity of the selective general control nonderepressible 2 (GCN2) activator DCC-2812 as monotherapy in advanced/metastatic renal cell carcinoma (RCC), urothelial carcinoma, and castration-resistant prostate cancer.

Eligibility

Key Inclusion Criteria:

  • Have confirmed Advanced or Metastatic Renal Cell Carcinoma, Urothelial Cancer, or Castration-Resistant Prostate Cancer
  • Able to take oral medication
  • If a female is of childbearing potential, must have a negative pregnancy test prior to enrollment and all participants agree to follow the contraception requirements
  • Adequate organ function and electrolytes

Key Exclusion Criteria:

  • Received any prior anticancer therapy or any investigational therapy within a specified timeframe prior to first dose of DCC-2812
  • Impaired cardiac function
  • Major surgery within 28 days of the first dose of study drug

Study details
    Renal Cell Carcinoma
    Urothelial Carcinoma
    Castration-resistant Prostate Cancer

NCT06966024

Deciphera Pharmaceuticals, LLC

15 October 2025

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