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Digital Measures for Clinical Trial Endpoints in Huntington's Disease

Digital Measures for Clinical Trial Endpoints in Huntington's Disease

Recruiting
25-60 years
All
Phase N/A
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

MEND-HD is a longitudinal study evaluating the feasibility of passive monitoring of gait and chorea in patients with HD and the meaningfulness of these outcomes for patients with HD and their care partners/support persons.

Participants will take part in four virtual visits with study investigators to answer survey questions on movement and cognition, perform in-home movement assessments, and take part in an interview regarding the meaningfulness of gait and chorea in their daily lives.

Participant and care partner interviews will be used for symptom mapping and qualitative data analysis to assess the relevance and impact of the targeted symptoms on the participant's daily life.

Eligibility

Inclusion Criteria:

  • Inclusion Criteria for participants with adult-onset HD:
  • Age of 25-60 years.
  • Genetically confirmed HD (HD-ISS Stage 2 or early Stage 3)
  • English speaking.

Inclusion Criteria for control participants:

  • Age of 25-60 years.
  • English speaking.

Inclusion Criteria for support persons:

  • Self-identified support person or family member of the enrolled participants with HD.
  • 18 years or older
  • English speaking.

Exclusion Criteria:

  • Diagnosis of juvenile-onset HD.
  • History of co-morbid neurological disease or disorders such as stroke, multiple sclerosis, or moderate to severe
  • Traumatic Brain Injury.
  • Use of an assistive device for ambulation.
  • Montreal Cognitive Assessment (MoCA) score of 18 or lower
  • Acute or chronic medical conditions that significantly impact gait or mobility in the opinion of the investigator, e.g. ankle sprain or fracture, or any orthopedic,
  • cardiovascular or psychiatric disease.
  • Pregnancy
  • Cannot be enrolled into a blinded intervention trial at Baseline

Study details
    Huntington Disease
    Healthy

NCT07010705

University of Rochester

15 October 2025

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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